Sure, Highway 278 running through Bluffton on the way to Hilton Head Island is chock-a-block full of big boxes and name-brand outlets. For those seeking one-of-a-kind local finds inspired by the surrounding beauty, Old Town Bluffton on Highway 46/May River Road begs you to take your time and to browse. Stroll at your leisure among bespoke boutiques, filled with unique clothes and accessories, such as Spartina 449, a homegrown handbag and accessories line.